DETAILS, FICTION AND PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation factor eIF2α. The resulting translational arrest blocks viral replication. PKR belongs into a conserved family members of 4 protein kinases (PKR, click here PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to unique stimuli12, triggering the bu